Transverse maxillary constriction and maxillary crowding in children are problems commonly encountered and treated by orthodontists. Interceptive orthodontics with maxillary expansion (ME) is one of the treatment options recommended for children with transverse deficiencies with the intent to increase the transverse widths of the maxilla. A clear aligner maxillary expansion protocol has been proposed (Invisalign First, Align Technology, Inc., San José, CA, USA). Aligners could overcome some of the limitations presented by palatal expander particularly in non cross bite cases. With these appliances it is possible to control the movement of all the teeth in the maxillary arch aiming to produce an initial alignment and leveling while expanding the arch. Aligners can be really helpful in controlling maxillary first molars not only on the frontal plane, but on the horizontal and sagittal planes too, avoiding all the issues related to potential periodontal problems reported for conventional palatal expanders. Furthermore aligners can control the expansion limiting it to the anterior region of the arch to generate adequate space for the spontaneous alignment of the permanent upper lateral incisors prior to complete eruption. Functional treatment of growing Class II patients during their pubertal growth spurt can bring about significant skeletal and dentoalveolar modifications. The Invisalign Mandibular Advancement appliance is designed in order to obtain progressive advancement of the mandible with steps of 2 mm every 8 aligners. The progressive advancement of the mandible has been demonstrated to be more effective in producing skeletal outcomes both in animal and human studies. A research conducted at the University of Torino italy showed significant skeletal effects. A sample of patients treated with Invisalign First and Invisalign MA has been collected and pros and cons of those treatments will be discussed highlighting potentials and limitations.